Evaluation of peak cough flow in Brazilian healthy adults
© Cardoso et al.; licensee BioMed Central Ltd. 2012
Received: 3 May 2012
Accepted: 25 September 2012
Published: 28 September 2012
In this study we aimed to evaluate the peak cough flow (PCF) in healthy Brazilian subjects.
We evaluated 484 healthy subjects between 18 and 40 years old. Subjects were seated and oriented were asked to perform a maximal inspiration followed by a quick, short and explosive expiration on the peak flow meter. Three measures were carried out and recorded the average of the three results for each individual.
The PCF values ranged between 240 and 500 L/min. The PCF values were lower in females than in males. The PCF was inversely proportional to age.
The values for Brazilian adult healthy subjects regarding PCF were between 240 and 500 L/min.
KeywordsRespiration Cough Peak expiratory flow rate Physiology
Among the methods used to evaluate pulmonary function, we may include some parameters such as forced vital capacity , total lung capacity  and peak expiratory flow (PEF) . PEF is a maximum flow generated during a forced expiration after lung inflation, i.e., starting from total lung capacity (TLC) [3–5].
Respiratory disorders impairs quality of life in several ages [6–8]. Along with PEF, peak cough flow (PCF) has provided clinical data to identify common variations in the respiratory muscles function [3–5]. Respiratory and neuromuscular diseases induce respiratory muscles weakness, resulting in accumulation of secretions in the airways, leading to pneumonia development, tracheal intubation and tracheostomy .
Due to respiratory changes, which results in ineffective cough, it is believed that the development of a PCF normative values in normal individuals from Brazil is important to early detect values below the reference from normal and intervene in respiratory muscle training and cough. Therefore, we aimed to evaluate the PCF in Brazilian healthy adult subjects.
We selected 484 healthy Caucasian Brazilian individuals according to spirometric values from public institutions in São Paulo city between March 2009 and August 2009, which were submitted to the PCF test. All subjects presented normal respiratory function according to the American Thoracic Society . We considered the following exclusion criteria: smokers, cardiopulmonary disorders, neurological and other impairments that prevent the subject known to perform the procedures, treatment with drugs that influence respiratory function and body mass index (BMI) below 20 kg/m2 and above 25 kg/m2. Participants in this study signed a consent form. The study was approved by the Ethics in Research of the School of Medicine of ABC (No. 009/2009).
Average peak cough flow values (L/min) in men and women according to age
Men - Mean ± SD (n)
Women - Mean ± SD (n)
499 ± 51 (10)
355 ± 31 (10)
486 ± 48 (10)
320 ± 29 (10)
484 ± 47 (10)
327 ± 34 (10)
435 ± 49 (10)
314 ± 28 (10)
428 ± 36 (10)
313 ± 25 (10)
407 ± 39 (10)
313 ± 34 (10)
406 ± 43 (10)
302 ± 33 (10)
494 ± 34 (10)
302 ± 31 (10)
486 ± 37 (10)
310 ± 30 (10)
484 ± 45 (10)
304 ± 24 (10)
439 ± 35 (10)
298 ± 23 (10)
430 ± 41 (10)
297 ± 31 (10)
426 ± 44 (10)
296 ± 38 (10)
410 ± 39 (10)
286 ± 25 (10)
399 ± 32 (10)
295 ± 36 (10)
380 ± 41 (10)
285 ± 21 (10)
380 ± 33 (10)
282 ± 29 (10)
376 ± 32 (10)
280 ± 34 (10)
381 ± 43 (10)
278 ± 35 (10)
360 ± 33 (10)
279 ± 21 (10)
347 ± 49 (10)
262 ± 30 (10)
337 ± 39 (10)
258 ± 23 (10)
316 ± 38 (10)
242 ± 34 (10)
Subjects were seated and asked to perform a voluntary couch. The volunteers performed a maximal inspiration, followed by a quick, short and explosive expiration on the peak flow meter. The difference from the peak expiratory flow is the higher glottis pressure and the higher resistance induced by the closed glottis, which characterizes a forced cough. Three measures were carried out and we considered the average of three results for each individual. It was performed a total of 1380 PCF measures in 460 subjects (230 men).
The peak flow meter used was the Mini-Wright Peak Flow Meter Clement Clarke International Ltd., portable, easy to handle and made of plastic material. It was used in order to assess the strength and speed exerted by the expiration in liters per minute (L/min). During the period we used our mechanical tool we did not realize any damage of the instrument [5, 11].
We applied the Kolmorogov-Smirnov normality test in order to evaluate the distributions. Considering that all distributions were parametric, we applied the Student t test to compare PFC between men and women and the Pearson correlation coefficient to verify the correlation between age and PFC. Differences were considered significant when the probability of a type I error was less than 5% (p < 0.05). We used the software SPSS 11.5 for Windows.
The PCF values ranged from 240 to 500 L/min in relation to the whole group. In males mean PCF values ranged from 316 L/min to 499 L/min and in females it ranged from 242 L/min to 355 L/min.
In Table 1 we observed that there was a significant decrease in the PCF in men according to age. In women we found that there was a decrease in PCF without major modifications. The female data are homogeneous compared to males, which presented a major difference between ages.
The both groups presented a relative decrease of the PEF according to the age. There was a significant correlation between PEF and age for both groups (r = −0.851; p = 0.001 for men and r = −0.941; p = 0.001 for women).
Based on our data, the values for PCF in Brazilian healthy adults ranged between 240 and 500 L/min. The PCF correlates with respiratory muscle strength, especially with inspiratory muscle strength. In the inspiratory phase of cough, inhalation of high volumes promotes a relationship of time and tension of the muscles and increases the elastic recoil of the respiratory system, optimizing expiratory pressures. The muscle strength to inhale appropriate volumes lead to chest expansion and the muscle force to increase intrathoracic pressure are important to generate effective cough and high flows .
One of the limitations of the voluntary evaluation of PCF is the understanding and cooperation of the subjects. Also, the cough reflex mechanism would be triggered by a reasonable way to replacing the method of evaluation. The differences in voluntary and reflex cough go beyond the way they are triggered. However, there are differences in how muscle action is triggered .
Our data showed that there are minimal changes between ages, and we observed in our sample that it may not be changed due to the no comprehension of the subject, since we excluded those who did not comprehend the test. During the voluntary cough the expiratory and accessories muscles action only generates one PCF. On the other hand, during the reflex cough the muscle action is harmonious and simultaneous, generating two or more peak expiratory flow of lower amplitude .
According to our results, the PCF values ranged from 240 to 500 L/min. According to the literature, in healthy individuals, the average PCF is higher than 300 L/min in Caucasian European subjects. Additionally, the PCF must be higher than 160 L/min for an effective cough according to the literature .
Our findings were obtained from healthy subjects without decrease in muscle strength. The consequence of an inspiratory muscle weakness is the loss of ability to perform a deep inspiration, which is necessary to maintain peripheral alveolar ventilation in addition to affecting the first phase of cough (deep breath). The weakness of the expiratory muscles may be seen in a reduction in maximal expiratory pressure, reduced ability to perform a deep expiration and cough .
We found some difficulties such as lack of reference to studies in relation to similar themes or methodologies on the PCF values. Furthermore, there were difficulties in the selection of the subjects, which limited the study sample.
The intent of this study was to evaluate PCF in a cohort of healthy Brazilian subjects. However, age range was not large enough; therefore, it is hard to develop prediction equations from the values we obtained. We suggest future studies to provide prediction equations for this variable. This equation would provide a reference against which measurements from patients with respiratory muscle weakness could be compared in order to identify early those at risk of problems with cough and secretion clearance. While normative values for other aspects of respiratory function such as PEF, TLC and maximum inspiratory and expiratory muscle strength are available, this is not the case for PCF, and therefore, normative data would be very important. This information could be used in developing prevention programs by identifying and intervening in patients at risk.
In this study we investigated PCF in Brazilian healthy adults (between 240 and 500 L/min). The PCF was inversely proportional to age, the higher the age the lower the PCF in both genders.
This study received financial support from Universidade Cruzeiro do Sul. The manuscript publication charges were paid by UNESP.
- Ruivo S, Viana P, Martins C, Baeta C: Effects of aging on lung function. A comparison of lung function in healthy adults and the elderly. Rev Port Pneumol 2009, 15:629–653.PubMedGoogle Scholar
- Marek W, Marek EM, Mückenhoff K, Smith HJ, Kotschy-Lang N, Kohlhäufl M: Lung function in our aging population. Eur J Med Res 2011, 16:108–114.PubMedView ArticleGoogle Scholar
- Naehrig S, Lang S, Schiffl H, Huber RM, Fischer R: Lung function in adult patients with cystic fibrosis after using the eFlow rapid for one year. Eur J Med Res 2011, 16:63–66.PubMedView ArticleGoogle Scholar
- Lima IS, de Moura Filho O F, Cunha FV, Ribeiro JL, Valenti VE, de Abreu L C: Chest and Neck Mobilization Effects on Spirometric Responses in Healthy Subjects. J Manipulative Physiol Ther 2011, 34:622–626.PubMedView ArticleGoogle Scholar
- Radziavicius FR, Martins LC, Radziavicius CC, Valenti VE, Siqueira AA, de Souza CG, de Abreu LC: Peak expiratory flow values are higher in older and taller healthy male children: an observational study. Clin Invest Med 2010, 33:E92.PubMedGoogle Scholar
- de Abreu LC, Valenti VE, de Oliveira AG, Leone C, Siqueira AA, Herreiro D, Wajnsztejn R, Manhabusque KV, Júnior HM, de Mello Monteiro CB, Fernandes LL, Saldiva PH: Chest associated to motor physiotherapy improves cardiovascular variables in newborns with respiratory distress syndrome. Int Arch Med 2011, 4:37.PubMedView ArticleGoogle Scholar
- Palissery V, Veenith T, Siddaiah N, Brennan L: Internal dislocation of scapula following thoracotomy for lung transplantation - a case report. Int Arch Med 2009, 2:10.PubMedView ArticleGoogle Scholar
- Carvalho TD, Pastre CM, de Godoy MF, Fereira C, Pitta FO, de Abreu LC, Ramos EM, Valenti VE, Vanderlei LC: Fractal correlation property of heart rate variability in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2011, 6:23–28.PubMedView ArticleGoogle Scholar
- Tzeng AC, Bach JR: Prevention of Pulmonary Morbidity for patients with neuromuscular disease. Chest 2000, 118:1390–1396.PubMedView ArticleGoogle Scholar
- Guidelines for the evaluation of impairment/disability in patients with asthma. American Thoracic Society. Medical Section of the American Lung Association Am Rev Respir Dis 1993, 147:1056–1061.Google Scholar
- Dias de Carvalho T, Marcelo Pastre C, Claudino Rossi R, de Abreu LC, Valenti VE, Marques Vanderlei LC: Geometric index of heart rate variability in chronic obstructive pulmonary disease. Rev Port Pneumol 2011, 17:260–265.PubMedView ArticleGoogle Scholar
- Irwin RS, Boulet LP, Cloutier MM: Managing cough as a defense mechanism and as a symptom: a consensus panel report of the American College of Chest Physicians. Chest 1998, 114:133–175.View ArticleGoogle Scholar
- Wright BM: A miniarture Wright peak-flow meter. Brit Med J 1978, 2:1627–1628.PubMedView ArticleGoogle Scholar
- Gauld LM, Boynton A: Relationship between peak cough flow and spirometry in Duchenne muscular dystrophy. Pediatr Pulmonol 2005, 39:457–460.PubMedView ArticleGoogle Scholar
- MacDuff A, Ian S: Grant critical care management of neuromuscular disease, including long-term ventilation. Curr Opin Crit Care 2003, 9:106–112.PubMedView ArticleGoogle Scholar
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