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Table 2 Frequencies of HLA-DRB1 alleles in patients and control

From: Diagnostic performance and predictive value of rheumatoid factor, anti-cyclic-citrullinated peptide antibodies and HLA-DRB1 locus genes in rheumatoid arthritis

HLA-DRB1 allele Patients Control P value
HLA-DRB1-01 27(45%) 5(5%) 0.001
HLA-DRB1-02 11(18%) 0(0%) 0.05
HLA-DRB1-03 10(16%) 50(50%) 0.03
HLA-DRB1-04* 21(35%) 10(10%) 0.05
   - HLA-DRB1-0401 3(15%) 3(13%)  
   - HLA-DRB1-0404 1(5%) 9(9%)  
   - HLA-DRB1-0405 17(80%) 77(77%)  
DRB1*04 non-SE alleles 0 (0%) 1(1%)  
HLA-DRB1-07 4(6%) 25(25%) 0.02
HLA-DRB1-08 6(10%) 5(5%) NS
HLA-DRB-09 1(1.7%) 1(1%) NS
HLA-DRB1-10 0(0%) 15(15%) 0.002
HLA-DRB1-11 5(8.3%) 20(20%) NS
HLA-DRB-12 10(16%) 16(16%) NS
HLA-DRB-13 16(26.7%) 30(30%) NS
HLA-DRB-14 1(1.7%) 4(4%) NS
HLA-DRB1-15 0(0%) 16(16%) 0.002
  1. Values are expressed as n (%). HLA: human leukocyte antigen. *According to HLA-DRB1*04 subtyping the shared epitopes encoding alleles *0409, *0413, *0416 and *0421 were classified as *0401 alleles, *0408, *0410 and *0419 were classified as *0404. The DRB1*0405 alleles were analyzed as a separate entity. All other DRB1*04 alleles were classified as DRB1*04 non-SE alleles.(4)