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Table 3 Univariate predictors of disease activity grade

From: Diagnostic performance and predictive value of rheumatoid factor, anti-cyclic-citrullinated peptide antibodies and HLA-DRB1 locus genes in rheumatoid arthritis

  Sensitivity Specificity PPV NPV P value
Anti-CCP present 97% 36% 68% 90% 0.001
RF present 77% 36% 63% 53% NS
CRP > 18 37% 72% 100% 51% 0.002
ESR1 > 32 89% 40% 67% 71% 0.014
ANA 20% 68% 51% 45% NS
AKA 65% 68% 74% 59% 0.01
Age > 50 29% 80% 67% 44% NS
Duration > 6m 97% 8% 60% 67% NS
Smoking 9% 92% 60% 42% NS
Larsen score ≥35 80% 48% 68% 63% 0.02
HLA-DRB1*01 40% 48% 51% 36% NS
HLA-DRB1*04 48% 84% 81% 54% 0.009
  1. AKA: antikeratin antibody; anti-CCP: anti-cyclic citrullinated peptides antibodies; ANA: antinuclear antibodies; CRP: C-reactive protein; HLA: human leukocyte antigen; NPV: negative predictive value; PPV: positive predictive value; RF: rheumatoid factor