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Table 5 Univariate predictors of radiological joint damage (Larsen score)

From: Diagnostic performance and predictive value of rheumatoid factor, anti-cyclic-citrullinated peptide antibodies and HLA-DRB1 locus genes in rheumatoid arthritis

  Sensitivity Specificity PPV NPV P value
Anti-CCP present 90% 32% 74% 60% 0.05
RF present 81% 47% 77% 53% 0.03
CRP > 18 66% 63% 79% 46% 0.05
ESR1 > 32 98% 68% 87% 93% 0.0001
ANA 21% 74% 73% 37% NS
AKA 56% 58% 74% 38% NS
Age > 50 32% 90% 86% 38% NS
Duration > 6m 98% 11% 70% 67% NS
Risk factor 7% 90% 60% 31% NS
HLA-DRB1*01 53% 74% 81% 42% 0.05
HLA-DRB1*04 44% 84% 86% 54% 0.04
  1. AKA: antikeratin antibody; anti-CCP: anti-cyclic citrullinated peptides antibodies; ANA: antinuclear antibodies; CRP: C-reactive protein; HLA: human leukocyte antigen; NPV: negative predictive value; PPV: positive predictive value; RF: rheumatoid factor.