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Table 5 Univariate predictors of radiological joint damage (Larsen score)

From: Diagnostic performance and predictive value of rheumatoid factor, anti-cyclic-citrullinated peptide antibodies and HLA-DRB1 locus genes in rheumatoid arthritis

 

Sensitivity

Specificity

PPV

NPV

P value

Anti-CCP present

90%

32%

74%

60%

0.05

RF present

81%

47%

77%

53%

0.03

CRP > 18

66%

63%

79%

46%

0.05

ESR1 > 32

98%

68%

87%

93%

0.0001

ANA

21%

74%

73%

37%

NS

AKA

56%

58%

74%

38%

NS

Age > 50

32%

90%

86%

38%

NS

Duration > 6m

98%

11%

70%

67%

NS

Risk factor

7%

90%

60%

31%

NS

HLA-DRB1*01

53%

74%

81%

42%

0.05

HLA-DRB1*04

44%

84%

86%

54%

0.04

  1. AKA: antikeratin antibody; anti-CCP: anti-cyclic citrullinated peptides antibodies; ANA: antinuclear antibodies; CRP: C-reactive protein; HLA: human leukocyte antigen; NPV: negative predictive value; PPV: positive predictive value; RF: rheumatoid factor.
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