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Table 1 Clinical outcome in patients taking statins before the incident of stroke

From: Statins and clinical outcome of acute ischemic stroke: a systematic review

Study

NIHSS

mRS

Other clinical measures (BI, imaging)

Martí-Fàbregas 2004 [14]

Not significantly different

mRS of 0-1 in 80% in statin group vs. 61.3% in non-statin group, P = 0.059

BI of 95-100 in 76.7% in statin group vs. 51.8% in non-statin group, P = 0.015

Yoon 2004 [15]

N/A

51% in statin group vs. 38% in non-statin group had mRS < 2; P = 0.03

 

Greisenegger 2004 [16]

N/A

6% in statin group vs. 14% in non statin group had a mRS of 5 or 6

 

Moonis 2005 [17]

Significantly more patients had NIHSS ≤ 2 in statin group vs. non-statin, P = 0.008

Significantly more patients had mRS ≤ 2 in statin group vs. non-statin, P = 0.045

 

Reeves 2008 [18]

N/A

35.9% in statin group had mRS ≥ 4 vs. 44.3% in non-statin group

 

Nicholas 2008

N/A

N/A

Statin pretreatment in patients with diabetes resulted in a smaller than median infarct volume after ischemic stroke (P = 0.01).

Stead 2009 [20]

Not significantly different

Patients on statins were significantly more likely to have a mRS ≤ 2

 

Goldstein 2009 [21]

Not significantly different

a trend toward reduced disability with stains based on mRS (P = 0.0647)

 
  1. BI, Barthel Index; mRS, modified Rankin Scale; N/A, not available; NIHSS, National Institutes of Health Stroke Scale