Figure 3From: Midkine as a factor to counteract the deposition of amyloid β-peptide plaques: in vitro analysis and examination in knockout mice Deposition of Aβ is enhanced in the brain of mice deficient in the midkine gene. (A), Representative tissue section (cortex and hippocampus region) from a 15-month-old mouse brain immunostained with mouse monoclonal anti-Aβ antibody. MKKO brain sections showed an increase in immunoreactitivity for Aβ compared with WT, PTNKO or DKO brain. Bar: 200 μm. (B), Quantification of the number of Aβ plaques in A. Deposits of Aβ with a width of more than 25 μm in the cerebral cortex and hippocampus were measured and counted using a system microscope. The number of sections was more than 15 in each brain. The number of 15-months-old female mice used was 6 for each genotype, and data are presented as the mean ± S.E. *P < 0.01 compared with WT.Back to article page