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Figure 3 | International Archives of Medicine

Figure 3

From: Midkine as a factor to counteract the deposition of amyloid β-peptide plaques: in vitro analysis and examination in knockout mice

Figure 3

Deposition of Aβ is enhanced in the brain of mice deficient in the midkine gene. (A), Representative tissue section (cortex and hippocampus region) from a 15-month-old mouse brain immunostained with mouse monoclonal anti-Aβ antibody. MKKO brain sections showed an increase in immunoreactitivity for Aβ compared with WT, PTNKO or DKO brain. Bar: 200 μm. (B), Quantification of the number of Aβ plaques in A. Deposits of Aβ with a width of more than 25 μm in the cerebral cortex and hippocampus were measured and counted using a system microscope. The number of sections was more than 15 in each brain. The number of 15-months-old female mice used was 6 for each genotype, and data are presented as the mean ± S.E. *P < 0.01 compared with WT.

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