Figure 2

Chromatograms under LC/MS/MS conditions for analyzing beagle dog plasma spiked with Notoginsenoside R1 (A), Ginsenoside Rg1 (B), Ginsenoside Rb1 (C) and internal standard glipizide (D). MS/MS transitions monitored in the positive ion mode were from m/z 1007 to m/z 423 for R1 (MW 932), from m/z 875 to m/z 423 for Rg1 (MW 800), from m/z 1183 to m/z 487 for Rb1 (MW 1108), and from m/z 494 to m/z 369.1 for internal standard. Intensity cps: ion intensity is in counts per second. The retention time is 1.67 min for R1, 1.56 min for Rg1, 3.81 min for Rb1 and 1.86 min for I.S.