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Table 1 Pharmacokinetic parameters of Notoginsenoside R1, Ginsenoside Rg1 and Rb1 after oral administration of PNS normal and bio-adhesive tablets (50 mg/kg) to dogs (n = 6)

From: Pharmacokinetics study of bio-adhesive tablet of Panax notoginseng saponins

  R1 Rg1 Rb1
  NT BT NT BT NT BT
Tmax(h) 2.67 5.00* 2.33 3.33* 9.33 10.67*
Cmax(ng/mL) 27.83 47.69* 55.58 42.03 1090.45 2448.90*
MRT(h) 9.93 9.19 6.40 11.54* 26.38 26.68
AUC(ng/mL)Sh 132.11 270.21* 199.08 304.06* 35579.73 53546.15*
  1. NT: normal tablet; BT: Bio-adhesive tablet
  2. * P < 0.05 versus oral administration of normal tablet.