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Table 1 Pharmacokinetic parameters of Notoginsenoside R1, Ginsenoside Rg1 and Rb1 after oral administration of PNS normal and bio-adhesive tablets (50 mg/kg) to dogs (n = 6)

From: Pharmacokinetics study of bio-adhesive tablet of Panax notoginseng saponins

 

R1

Rg1

Rb1

 

NT

BT

NT

BT

NT

BT

Tmax(h)

2.67

5.00*

2.33

3.33*

9.33

10.67*

Cmax(ng/mL)

27.83

47.69*

55.58

42.03

1090.45

2448.90*

MRT(h)

9.93

9.19

6.40

11.54*

26.38

26.68

AUC(ng/mL)Sh

132.11

270.21*

199.08

304.06*

35579.73

53546.15*

  1. NT: normal tablet; BT: Bio-adhesive tablet
  2. * P < 0.05 versus oral administration of normal tablet.
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