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Table 3 Risk factors associated with increased odds of in-hospital mortality in elderly patients with bacteraemia (univariate analysis).

From: Predictors of in-hospital mortality in elderly patients with bacteraemia admitted to an Internal Medicine ward

  Survived
n = 105
Died
n = 30
   
  n (%) c n (%) d OR (95%CI) P
Gender:        
Male 55 (52.4) 18 (60.0) 1.0 (reference group)  
Female 50 (47.6) 12 (40.0) 0.733 (0.321-1.673) 0.460
Age:        
65-74 yrs 23 (21.9) 8 (26.7) 0.755 (0.266-2.148) 0.097
75-84 yrs 54 (51.4) 9 (30.0) 0.326 (0.120-0.883)  
≥ 85 yrs 28 (26.7) 13 (43.3) 1.0 (reference group)  
Admission from:        
   Home 74 (70.5) 21 (70.0) 0.977 (0.403-2.372) 0.960
   Nursing-home 31 (29.5) 9 (30.0) 1.0 (reference group)  
Bedridden state 57 (54.3) 20 (66.7) 1.676 (0.695-4.045) 0.247
Length of hospital stay 13 (7-22) 12 (40.0) NA NA 0.760
Previous Hospital admissions 46 (43.8) 19 (63.3) 2.230 (0.943-5.275) 0.064
Appropiate antibiotic therapy 40 (38.1) 6 (20.0) 0.375 (0.139-1.010) 0.047
Comorbidities:        
   Cardiovascular disease 17 (16.2) 7 (23.3) 1.553 (0.573-4.214) 0.571
   Pulmonary disease 15 (14.3) 5 (16.7) 1.181 (0.389-3.578) 0.774
   Chronic renal disease 11 (10.5) 8 (26.7) 3.082 (1.103-8.611) 0.037
   Cerebrovascular disease 48 (45.7) 10 (33.3) 0.570 (0.056-4.023) 0.198
   Hypertension 29 (27.6) 10 (33.3) 0.765 (0.331-1.765) 0.571
   Diabetes Mellitus 32 (30.5) 8 (26.7) 0.810 (0.324-2.024) 0.651
   Dyslipidemia 7 (6.7) 1 (3.3) 0.474 (0.056-4.023) 0.862
Source of Infection        
   UTI 48 (45.7) 13 (43.3) 0.908 (0.401-2.057) 0.817
   LRI 41 (39.0) 7 (23.3) 0.475 (0.187-1.207) 0.113
   Skin ulcer infection 13 (12.4) 4 (13.3) 0.462 (0.127-1.679) 1.000
   Bacteraemiaa 3 (2.9) 4 (13.3) 1.071 (0.321-3.575) 0.045
   Miscellaneouse 7 (6.7) 2 (6.7) 1.000 (0.197-5.087) 1.000
Microorganism        
   MRSA 13 (12.4) 8 (26.7) 2.549 (0.937-6.940) 0.085
   NMRSA 15 (14.3) 5 (16.7) 1.181 (0.389-3.578) 0.774
    Enterococcus faecalia 12 (11.4) 2 (6.7) 0.543 (0.114-2.579) 0.735
    E. coli 23 (21.9) 3 (10.0) 0.386 (0.107-1.393) 0.135
   K. pneumoniae 12 (11.4) 4 (13.3) 1.173 (0.348-3.957) 0.796
   P. aeruginosa 4 (3.8) 4 (13.3) 3.840 (0.897-16.438) 0.075
Physiologic presentation        
Sepsis (SIRS + infection) 72 (68.6) 21 (70.0) 1.240 (0.376-4.086) 1.000
Functional status (ADL score ≥ 1) 76 (72.4) 26 (86.7) 2.737 (0.761-9.845) 0.111
Cognitive impairmentb 49 (46.7) 22 (73.3) 3.207 (1.256-8.188) 0.012
pO2 ≤ 59.65 mmHg 25 (23.8) 11 (36.7) 4.730 (1.361-16.444) 0.010
Albumin ≤ 3.05 g/dl 26 (24.8) 13 (43.3) 2.615 (1.072-6.380) 0.031
Temperature:        
< 36°C 4 (3.8) 5 (16.7) 1.0 (reference group)  
36-37.5°C 43 (41.0) 15 (50.0) 0.279 (0.066-1.178) 0.016
> 37.5aC 53 (50.5) 9 (30.0) 0.136 (0.031-0.604)  
  1. a Bacteraemia without an identifiable source of infection
  2. b moderate to severe cognitive impairment defined as having a SPMSQ score > 4
  3. c, d percentage calculated on the basis of the total number of survivors and deaths, respectively
  4. e Including central nervous system, muscle and bone infection
  5. CI = Confident interval, LRI- Lower respiratory infection, UTI- Urinary tract infection, SIRS- systemic inflammatory response syndrome, NA- not available