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Table 4 PANSS, GAF, and SAS at baseline and after six and twelve weeks of treatment

From: Efficacy and tolerability of quetiapine versus haloperidol in first-episode schizophrenia: a randomized clinical trial

   Haloperidol (n = 33) Quetiapine (n = 40) t-test p value
PANSS positive Baseline 23.8 ± 5.12 26.0 ± 4.41 1.90 0.06
  6 weeks 18.2 ± 5.90 21.3 ± 2.51 2.86 0.006
  12 weeks 18.9 ± 7.84 15.3 ± 2.18 2.55 0.013
PANSS negative Baseline 22.2 ± 8.51 21.3 ± 6.38 0.48 0.63
  6 weeks 20.4 ± 8.28 18.9 ± 6.21 0.86 0.39
  12 weeks 15.5 ± 7.39 11.6 ± 4.76 2.59 0.012
PANSS general psychopathology Baseline 39.0 ± 11.01 43.4 ± 8.36 1.939 0.056
  6 weeks 35.1 ± 11.30 37.3 ± 11.01 0.79 0.43
  12 weeks 23.8 ± 6.24 27.7 ± 6.33 2.58 0.012
PANSS depression/anxiety Baseline 10.18 ± 2.11 9.88 ± 1.92 0.6 0.55
  6 weeks 9.88 ± 1.95 9.29 ± 1.64 1.53 0.183
  12 weeks 9.56 ± 1.87 4.74 ± 1.50 11.92 <0.0001
PANSS total Baseline 82.3 ± 21.88 90.8 ± 11.32 1.939 0.056
  6 weeks 73.8 ± 19.50 77.6 ± 8.90 1.02 0.31
  12 weeks 58.3 ± 16.59 54.8 ± 5.93 1.17 0.24
GAF Baseline 32.4 ± 12.03 31.3 ± 7.36 0.47 0.63
  6 weeks 39.5 ± 10.28 40.0 ± 5.69 0.29 0.77
  12 weeks 45.7 ± 9.52 46.2 ± 6.17 0.26 0.79
SAS Baseline - - - -
  6 weeks 5.94 ± 1.83 0.18 ± 0.38 18.020 <0.0001
  12 weeks 8.62 ± 2.08 0.26 ± 0.45 22.949 <0.0001
  1. Values given are mean ± standard deviation. GAF = Global Assessment of Functioning; PANSS = Positive and Negative symptoms Scale; SAS = Simpson Angus scale.