https://intarchmed.biomedcentral.com/articles/10.1186/1755-7682-7-43
https://intarchmed.biomedcentral.com/articles/10.1186/1755-7682-7-45
https://intarchmed.biomedcentral.com/articles/10.1186/1755-7682-7-46
https://intarchmed.biomedcentral.com/articles/10.1186/1755-7682-7-44