https://intarchmed.biomedcentral.com/articles/10.1186/1755-7682-7-48
https://intarchmed.biomedcentral.com/articles/10.1186/1755-7682-7-47
https://intarchmed.biomedcentral.com/articles/10.1186/1755-7682-7-49
https://intarchmed.biomedcentral.com/articles/10.1186/1755-7682-7-50