- Case report
- Open Access
Concurrent reactive arthritis and myelitis – a case report
© Agarwal et al. 2009
Received: 19 January 2009
Accepted: 02 June 2009
Published: 02 June 2009
Reactive arthritis is a post infectious multisystem illness which usually occurs after episodes of diarrhoea or urinary tract infections. It can cause many manifestations other than the musculoskeletal system including skin, urogenital system and eyes. However the central nervous system is only occasionally involved. We discuss the case of a 32 year old male who presented with myelitis in association with reactive arthritis.
Reactive arthritis is a post infectious form of joint involvement which usually antedates episodes of diarrhoea or urinary tract infections. It can cause many manifestations involving the musculoskeletal system, skin, urogenital system, eyes or heart. Central nervous system manifestations are infrequent. Here we present the case of a middle aged male who had spinal cord involvement in form of myelitis in association with reactive arthritis. We could come across only two past reports of such coexistence.
A 32 year old male presented to us with complaints of pain and swelling of multiple joints of one month duration. The symptoms started in the right knee but soon involved the left knee, both ankles and hips. The pain was associated with morning stiffness which persisted for around one hour. Small joints of the hand were not involved. There were no ocular complaints. The patient also complained of backache which began at around the same time as the joint pain. No complaints of numbness, parasthesias, root pain, falls, and bladder or bowel symptoms were present. A fortnight later the patient developed skin lesions which began as fluid filled lesions over the back and later involved all limbs and the forehead. The patient also complained of some lesions over the penis. The patient gave history of multiple unprotected extramarital sexual contacts. He gave a history of dysuria prior to the onset of joint pains. He was a chronic smoker and occasionally took alcohol.
In a young male presenting with acute inflammatory additive polyarthritis with evidence of spondyloarthropathy developing after a urinary tract infection, the possibility of acute Reactive Arthritis has to be considered. The presence of psoriasiform rash and circinate balanitis raised the possibility of psoriatic arthritis. However, the appearance of joint symptoms prior to the rash is only occasionally seen in psoriasis. Also, the HLA – B 27 positivity favors Reactive Arthritis. HLA – B 27 can be positive in axial involvement in psoriatic arthritis but is less common with appendicular involvement. The presence of enthesitis (tenderness over spine), aortic root dilatation, sacroilitis, circinate balanitis and skin lesions beginning as vesicles were all consistent with Reactive Arthritis.
However the interesting finding in this case was the presence of bilateral lower limb hypereflexia, extensor plantar response and presence of clonus raising the possibility of compressive myelopathy due to spondylitis. The MRI of the dorsal spine revealed evidence of patchy myelitis. Interestingly the occurrence of both the reactive arthritis and myelitis was temporally related. There are only a few previous reports of coexistence of Reactive Arthritis with myelitis. In one (Neuromyelitis optica) this was explained as probably coincidental . Here a lady who had been having recurrent episodes of myelitis later developed reactive arthritis. Another report has indicted Reiter's as a cause of myelopathy in a 21 year old male . In this case a young male developed myelopathy associated with reactive arthritis secondary to a urinary tract infection.
The pathogenesis of both Reactive Arthritis and myelitis is explained on the basis of autoimmune phenomenon occurring in response to some infection. Multiple organisms are implicated in causation. Reactive arthritis is known to follow genitourinary and gastrointestinal infections, usually bacterial. Postinfectious myelitis usually follows viral infections. However myelitis can follow bacterial infections including Campylobacter and Yersinia . It is likely that a single preceding insult was responsible for the causation of Reactive Arthritis and myelitis in this case. Unfortunately no etiogic agent could be identified. The patient responded to high dose broad spectrum antibiotics, intravenous methylprednisolone followed by oral prednisolone. The hypereflexia disappeared and the plantars became flexor.
This case highlights the concurrent occurrence of Reactive Arthritis and myelitis. To dismiss this merely as a coincidence might not be appropriate in view of the common mechanisms involved in causation of these two phenomena. Preceding infection and autoimmune response to the infection are believed to be responsible for both and it is attractive to indict a single agent in causation
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Taurog JD: The spondyloarthritides. 17 Edition (Edited by: Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL). New York. McGraw-Hill 2008, 2109–19.Google Scholar
- Cox A, Coles A, Antoun N, Malik O, Lucchinnetti C, Compston A: Recurrent myelitis and optic neuritis in a 29-year-old woman. Lancet Neurol 2005, 4:510–6.View ArticlePubMedGoogle Scholar
- Montanaro A, Bennett RM: Myelopathy in Reiter's disease. J Rheumatol 1984, 11:540–1.PubMedGoogle Scholar
- Aberle J, Kluwe J, Pawlas F, Stellbrink HJ, Greten H: Severe Myelitis Following Infection with Campylobacter enteritis. Eur J Clin Microbiol Infect Dis 2004, 23:134–135.View ArticlePubMedGoogle Scholar
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