- Case report
- Open Access
A case of pericardial tuberculoma presenting as a left anterior chest wall mass
© Leye et al.; licensee BioMed Central Ltd. 2013
- Received: 24 June 2013
- Accepted: 12 December 2013
- Published: 19 December 2013
Tuberculosis (TB) can present both in its pulmonary or extra-pulmonary forms. Cardiac tuberculoma previously described only after autopsy is continuously seen with the advent of more advanced imaging modalities.
A 23-year-old male with a four month history of a progressively increasing left anterior thoracic wall mass of 5 cm in diameter was referred from oncology for clinical re-evaluation and for echocardiography. Systemic examination was essentially normal. Transthoracic and trans-oesophageal echocardiography showed the presence of a pericardial mass around the right atrioventricular junction. Thoracic CT scan showed an anterior mass in left chest wall extending to the pericardium and also the presence of mediastinal lymphadenopathy. Mantoux test was positive and histological examination of tissue biopsy confirmed the presence of TB. However, blood tests and culture of aspirated purulent fluid were unyielding. A diagnosis of pericardial tuberculoma with mediastinal and parietal extension was made and patient was successfully treated with standard anti-TB chemotherapy.
The possible differential diagnoses for chest wall tumors are varied and a high degree of suspicion is needed to diagnose cardiac tuberculoma especially in endemic regions. Imaging though helpful in morphological description cannot make precise diagnosis. The diagnosis depends on histological and culture studies. There is usually a good evolution with anti-TB treatment.
In an era of an increasing number of acquired immune-compromised patients, and with increasing number of diagnoses of tuberculosis, a diagnosis of cardiac tuberculoma should be considered in patients presenting with a thoracic wall mass.
- Pericardial tuberculoma
- Chest wall mass
Tuberculosis (TB) is a global health concern despite the widespread attention that it has received over the years. Pulmonary tuberculosis is the most commonly recognized form, however, extra-pulmonary manifestations of tuberculosis account for about 15-20% of cases [1, 2]. Tuberculous pericarditis, caused by Mycobacterium tuberculosis, is found in approximately 1% of autopsy cases and in 1% to 2% of cases of pulmonary TB . It is the most common cause of pericarditis in Africa and in other developing countries in which TB remains a major public health problem . Cardiac tuberculoma previously described only after autopsy is continuously seen with the advent of more advanced imaging modalities .
Cardiac tuberculosis was first reported by Maurocordat in 1664 and by Morgagni in 1761 . Cardiac tuberculomas can affect all four chambers of the heart, and simultaneous manifestations of tuberculomas at different locations have been reported. The right heart is mostly affected probably because of the frequent involvement of the right mediastinal lymph nodes with consequent spread to the myocardium .
The differential diagnosis of masses of the anterior and mid-mediastinum  includes thymomas, lymphomas, teratomatous neoplasms, thyroid masses, vascular masses, lymph node enlargement due to metastases or granulomatous disease, and pleuropericardial and bronchogenic cysts. Whereas the diagnosis of cardiac tuberculoma was almost exclusively made at autopsy previously, advances in imaging techniques give an opportunity for earlier diagnosis. These advanced imaging techniques may contribute to an optimal morphologic description, assessment of hemodynamic significance as well as their surveillance . However, they cannot help in distinguishing cardiac tuberculomas from other tumors. Generally, tissue diagnosis by endomyocardial biopsy and Ziehl-Neelsen staining are the most specific tests. However, this often fails to reveal the acid fast bacilli, and a definitive diagnosis depends on seeing typical histological changes. A culture of the organism can be done for definitive diagnosis.
Complete regression of tuberculoma treated with standard anti-TB chemotherapy has been reported  as in our case. Surgical intervention may be required in large tuberculoma when pharmacotherapy alone is inadequate and in cases of severe hemodynamic compromise, threatening thromboembolism or refractory arrhythmias .
We presented in this case a rare form of extra pulmonary TB. To our knowledge this is the first reported case in the literature in an immunocompetent patient with TB presenting as an anterior chest wall mass. A high index of suspicion is needed for its diagnosis especially in highly endemic regions as patients can be successfully treated with standard anti-TB chemotherapy. In an era of increasing number of acquired immuno-deficiency syndrome patients, and with increasing number of diagnoses of tuberculosis, a diagnosis of cardiac tuberculoma after a thorough clinical evaluation should be considered in patients presenting with a thoracic wall mass.
Written informed consent was obtained from the patient for publication of this Case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Batra R, Trehan V, Salwan R, Krishan A, Nigam M, Malhotra V, Kaul UA, Arora R: Antemortem diagnosis of cardiac tuberculoma. Indian Heart J 1998,50(1):87–89.PubMedGoogle Scholar
- Fanning A: Tuberculosis: extra pulmonary disease. CMAJ 1999, 160:1597–1603.PubMed CentralPubMedGoogle Scholar
- Fowler NO: Tuberculous pericarditis. JAMA 1991, 266:99–103.PubMedView ArticleGoogle Scholar
- Mayosi BM, Volmink JA, Commerford PJ: Pericardial disease: an evidence-based approach to diagnosis and treatment. In Evidence-based cardiology. 2nd edition. Edited by: Yusuf S, Cairns JA, Camm AJ, Fallen BJ. London: eBMJ Books; 2003:735–748.Google Scholar
- Mayosi BM, Burgess LJ, Doubell AF: Tuberculous pericarditis. Circulation 2005, 112:3608–3616.PubMedView ArticleGoogle Scholar
- Njovane X: Intramyocardial tuberculosis- a rare underdiagnosed entity. SAMJ 2009, 99:153–153.Google Scholar
- Jeilan M, Schmitt M, McCann G, Davies J, Leverment J, Chin D: Cardiac tuberculoma. Circulation 2008, 117:984–986.PubMedView ArticleGoogle Scholar
- Cantinotti M, De Gaudio M, de Martino M, Assanta N, Moschetti R, Veneruso G, Crocetti M, Murzi B, Chiappini E, Galli L: Intracardiac left atrial tuberculoma in an eleven month- old infant: case report. BMC Infect Dis 2011, 11:359.PubMedView ArticleGoogle Scholar
- Jouannic I, Pavin D, Seguin P, Arvieux C, Paumier V, Camus C, Le Tulzo Y, Leguerrier A, de Place C, Thomas R: Tuberculome cardiaque; intérêt de l’échographie cardiaque et discussion thérapeutique à propos d’un cas. Arch Mal Coeur Vaiss 1995,88(3):401–404.PubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.