Medication prescribing errors and associated factors at the pediatric wards of Dessie Referral Hospital, Northeast Ethiopia
© Zeleke et al.; licensee BioMed Central Ltd. 2014
Received: 15 July 2013
Accepted: 16 April 2014
Published: 3 May 2014
Medication error is common and preventable cause of medical errors and occurs as a result of either human error or a system flaw. The consequences of such errors are more harmful and frequent among pediatric patients.
To assess medication prescribing errors and associated factors in the pediatric wards of Dessie Referral Hospital, Northeast Ethiopia.
A cross-sectional study was carried out in the pediatric wards of Dessie Referral Hospital from February 17 to March 17, 2012. Data on the prescribed drugs were collected from patient charts and prescription papers among all patients who were admitted during the study period. Descriptive statistics was used to determine frequency, prevalence, means, and standard deviations. The relationship between dependent and independent variables were computed using logistic regression (with significance declared at p-value of 0.05 and 95% confidence interval).
Out of the 384 Medication order s identified during the study, a total of 223 prescribing errors were identified. This corresponds to an overall medication prescribing error rate of 58.07%. Incomplete prescriptions and dosing errors were the two most common types of prescribing errors. Antibiotics (54.26%) were the most common classes of drugs subjected to prescribing error. Day of the week and route of administration were factors significantly associated with increased prescribing error.
Medication prescribing errors are common in the pediatric wards of Dessie Referral Hospital. Improving quick access to up to date reference materials, providing regular refresher trainings and possibly including a clinical pharmacist in the healthcare team are recommended.
KeywordsMedication errors Prescribing errors Dessie Pediatrics
Optimal pharmacotherapy is achieved when the right drug with the correct dosage and quality reaches the right patient at the right time . However, medication error is common and preventable cause of iatrogenic injuries and may result in hospitalization, unnecessary diagnostic evaluations, unnecessary treatments, and death [2–5]. In 1999, an expert panel of the Institute of Medicine estimated that 44,000 to 98,000 people in the United States die each year as a result of medical errors, making medical error the sixth to ninth leading cause of death .
Every stage of the medication use process (storage, prescription, transcription, preparation, dispensation, and administration of a drug) is vulnerable to errors [7, 8], but errors are most frequent and common during prescribing and administration .
Medication error is particularly common in hospitalized patients specially among those who require multiple forms of pharmacological therapies, elderly, critically ill and pediatric patients . Incidence and consequences of medication errors are higher and potentially more harmful in the pediatric population than in th1e adult population . For adults, the reported incidence of errors ranges from 1% to 30% of all hospital admissions, or 5% of orders written while in pediatrics the number reported was as high as 15.6% of orders .
Pediatric inpatients are groups of patients more prone to medication errors because of different factors; weight-based dosing, the need for stock medicine dilution, decreased communication abilities of children and the high vulnerability of young and critically ill children to injury from medication (have a minor physiological reserve; immature renal and hepatic systems to compensate medication errors) [11, 13–15].
To ensure safety and quality of patient care preventing medication errors is important, and it can be easily done in the early stages of medication processing (prescribing and preparing the medication) but they are difficult in later stages . American Society of Health System Pharmacists (ASHP) recognizes that medication errors can be minimized by assessing the medication use process, identifying inadequacies within systems, and developing interventions to correct the recognized deficiencies .
Up to the investigator’s knowledge studies in this area are scanty in Ethiopia and no previous research was done in Dessie referral hospital. Therefore, this study was designed to determine prevalence of medication prescribing errors and underlying causes at the pediatric wards of Dessie Referral Hospital, Northeast Ethiopia.
Methods and participants
Study area and design
A cross-sectional study was conducted from February 17 to March 17, 2012 at Dessie referral hospital. The hospital is located in Dessie Town, Northeast Ethiopia, 401 km northeast of the capital city, Addis Ababa. Dessie referral hospital is the only referral hospital in this part of the country, with catchment population of seven million. The Hospital has 200 beds and 165 health professionals. The pediatric wards have 52 beds and 12 health professionals (2 general practitioners, 1 pediatrician and 9 nurses).
All medication prescribing interventions to all pediatric patients who were admitted to the pediatric inpatient wards during the study period were included. Data on prescribing interventions were collected from patient Charts and prescription papers.
Data collection procedures
Data on prescribed drugs were collected using a structured format from patient’s charts and prescription papers by two clinical pharmacists and one hospital pharmacist, who were oriented on how to extract the required data from patient charts. The contents of data collection format included patient demographics, diagnosis, diagnostic laboratory results, date of prescription, name of medication, dosage regimen (dose, frequency, dosage form, route of administration and duration) and type of prescribing error.
Data processing and analysis
Data was edited, coded, entered into SPSS for windows version 16.0. Descriptive statistics was used to determine frequency, prevalence, means, and standard deviations. Prevalence of error was calculated per 100 orders, per 100 administrations and 100 patient days. The relationship between dependent and independent variables was examined using logistic regression model. Level of statistical significance was set at p-value of 0.05 and confidence interval of 95%.
Approval and permission was obtained from the Institutional Review Board of College of Public Health and Medical Sciences of Jimma University. An official letter of cooperation was written from the Department of Pharmacy of Jimma University to the clinical director of the Dessie referral hospital. Data extraction from patient charts was conducted after obtaining written consent from the caretakers of the patients. All the data collection accessed in due course were kept confidential. To ensure confidentiality the names of patients were replaced with codes.
Definition of terms
● Prescribing error: Implies deviation of medication prescribing from standard practices and includes inappropriate (incorrect) drug selection, wrong dose, wrong frequency, wrong route and wrong dosage form. In this study, prescribing errors were identified by comparison of prescribed drugs with “national standard treatment guideline”  and “pocket book of Pediatric Hospital Care in Ethiopia” .
● Rate of prescribing errors: In this study it was calculated as the sum of each type of prescribing error to the total number of drugs orders.
● Patient days: The total sum of days each patient stayed in the hospital.
● Medication order: it is one prescribed item
● Incorrect drug selection: Prescribing potentially interacting drugs, contra indicated drugs and known allergies.
● Wrong frequency: Drug prescribed with a frequency that deviates from the recommended practices.
● Wrong dose (prescribed): Dose of the drug ordered is ±10% of the recommended dose.
● Wrong route: Drug prescribed other than the recommended route.
● Incomplete prescription: Missing essential information in the prescription, such as missing the route of administration, the dose intended by the prescriber, frequency or type of dosage form.
● Antibiotics: In this study referred to antibacterial drugs.
Characteristics of participants
During the 4 weeks, there were 150 admissions at the pediatric wards in Dessie Referral Hospital. Of these 136 admissions were included in this study and a total of 384 Medication order s were given for these patients over a period of 642 patient days.
Characteristics of patients admitted in pediatric ward of Dessie referral hospital, February 17 - March 17, 2012 (n = 136)
Neonate (birth - 28 day)
Infant (29 day - 1 year)
Toddler (1–3 year)
Preschool (3–5 years)
School age (6–10 years)
Adolescent (11–14 years)
Level of consciousness
Prevalence and nature of prescribing errors
Examples of medication prescribing errors in the pediatric ward of Dessie referral hospital, February 17 - March 17, 2012
Type of prescribing error
A 3 year old patient ,weight 10 kg, was prescribed ceftriaxone 250 mg IV BID instead of the correct dose of 500 mg IV BID in the treatment of meningitis
Diclofenac sodium 75 mg was prescribed to be given through IV instead the correct route IM route
Paracetamol suppositories: missing essential information about dose, frequency and route of administration
Both Dexamethasone 8 mg IV stat and dexamethasone 8 mg IV QID for 3 days were prescribed for the treatment of severe croup, while dexamethasone 8 mg QID for 3 days was unnecessary
Wrong dosage form
Amoxicillin syrup 125 mg/5 ml was prescribed instead of the correct dosage form which is suspension
Ampicillin 30 mg intravenous was prescribed four times a day instead of the correct frequency of twice a day for a one day old baby
Therapeutic category of medications associated with medication prescribing errors in the pediatric ward of Dessie referral hospital, February 17 - March 17, 2012
Analgesics and antipyretics
Top ten drugs associated with medication prescribing errors in the pediatric ward of Dessie referral hospital, February 17 - March 17, 2012
Specific drug name
Wrong dosage form
Total Frequency (%)
Predictors of prescribing error
Frequency and variables associated with prescribing errors at Dessie referral hospital, February 17 - March 17, 2012
No. of PEs
No. without PEs
Neonate (birth - 28 day)
Infant (29 day - 1 year)
(1.116 – 4.347)
Toddler (1–3 year)
(0.673 – 2.765)
Preschool (3–5 years)
(0.779 – 5.777)
School age (6–10 years)
(0.500 – 2.164)
Adolescent (11–14 years)
(0.534 – 2.362)
Route of administrations
(4.256 – 13.913)
(2.672 – 9.767)
Day of the week
Weekends and Holidays
(0.259 – 0.913)
Variables associated with prescribing errors in pediatric inpatients (Multivariate Analysis)
Day of the week
Weekends and holidays
(0.207 – 0.844)
Route of administration
(4.305 – 14.257)
(2.823 – 10.586)
This study was conducted with the intention of measuring the prevalence of medication prescribing errors and identifying predictors of errors in a resource limited setting. It was shown that 223 (58.07%) of the medication orders had some kind of medication prescribing error. Comparable proportion of medication prescribing errors were reported by an earlier study from Saudi Arabia (56%) , while the one from Egypt (78.1%) was much higher . At this point it has to be noted that wrong time of administration of intravenous drugs was included in the definition of medication prescribing error in the study from Egypt while this was not the case in the current study. On the other hand the result in this study was higher than those reported by Folli et al. (4.9 and 4.5 errors per 1000 medication orders in two US hospitals) , Condren et al. (9.7% in Tulsa, U.S.A)  and Ghaleb et al. (13.2% in five hospitals, London) . This difference may be ascribed to the differences in the hospital settings such as differences in training levels of prescribers, availability of support system and composition of health care team and difference in the definition of prescribing errors.
In this study, incomplete prescriptions, wrong dose, wrong dosage form and wrong frequency were the commonest types of medication prescribing errors. Similarly, incomplete prescriptions and wrong dosing were identified as the most common prescribing errors in other studies [20, 23]. Errors due to incomplete prescriptions might not result in immediate danger but would be expected to delay receipt of medications . On the other hand, dosing errors in pediatrics might result in toxicity due to over dose or sub therapeutic concentration and ineffective treatment.
It was revealed that the three most common drug classes involved in medication prescribing errors were antibiotics, analgesics and antipyretics and diuretics. Likewise, antibiotics were the most common classes of drugs involved in medication prescribing errors in previous studies from the UK  and USA [22, 24]. It might be probably antibiotics were among the most common drugs prescribed. On the other hand, paracetamol, amoxicillin and Ampicillin were the three most common drugs involved in prescribing error. It was observed that almost all of medication orders of paracetamol and amoxicillin were incomplete prescriptions which explains the why these drugs are top on this list.
With regard to predictors of prescribing error, day of the week and type of route of administration were found to be independent predictors of medication prescribing error in pediatric wards of the Dessie Referral Hospital. Intravenous route was less likely to be associated with prescribing error. This may partly be explained by the fact that prescribers take extra care while determining dose, frequency and route of drugs give through intravenous route. Moreover, it was found that majority of prescriptions for oral and other routes were incomplete. Rates of medication errors in different age groups were not significant but the peak was in the age group 29 days – 1 year, comparable to reports from Spain  and U.S.A .
On the other hand, unlike the findings of de Muga et al. , medication error rate was high when patients were seen during weekdays as compared to weekends and holidays. This might be attributed to the difference in number of prescribers and admitted patients during weekdays, weekends and holidays. It was observed that few patients were admitted during weekends and holidays.
Interpretation of the findings reported here needs consideration of the limitations of the study. Since the study included patients admitted to a single hospital generalization of findings must be made cautiously. This study did not relate the clinical consequence of the medication prescribing errors observed.
Medication prescribing errors were significantly high in the pediatric ward of Dessie referral hospital. Antibiotics were the most common class of drugs involved in medication errors. Day of the week and route of administration were independent predictors of medication prescribing error.
Physicians should take extra precautions when writing prescriptions (especially antibiotics) to pediatrics patients considering the consequences of errors in this group of patients. Development of system to report and prevent medication error in the pediatric wards is recommended. In the long term, development and implementation of a computerized physician order entry system, ward-based clinical pharmacists, and improving communication between health care workers in the hospital are recommended.
The authors would like to thank Jimma University for funding this research. They are also thankful caregivers of patients who willingly allowed us to use patient cards. Data collectors and staff at the pediatric wards of Dessie Referral Hospital also deserve appreciation for their cooperation during data collection.
- Krahenbuhl-Melcher A, Krahenbuhl S: Hospital drug safety: medication errors and adverse drug reactions. Praxis (Bern 1994) 2005,94(24–25):1031–1038.View ArticleGoogle Scholar
- Kozer E, Scolnik D, Macpherson A, Keays T, Shi K, Luk T, Koren G: Variables associated with medication errors in pediatric emergency medicine. Pediatrics 2002,110(4):737–742.PubMedView ArticleGoogle Scholar
- Kozer E, Berkovitch M, Koren G: Medication errors in children. Pediatr Clin North Am 2006,53(6):1155–1168.PubMedView ArticleGoogle Scholar
- Otero P, Leyton A, Mariani G, Ceriani Cernadas JM: Medication errors in pediatric inpatients: prevalence and results of a prevention program. Pediatrics 2008,122(3):e737-e743.PubMedView ArticleGoogle Scholar
- Tully MP, Ashcroft DM, Dornan T, Lewis PJ, Taylor D, Wass V: The causes of and factors associated with prescribing errors in hospital inpatients: a systematic review. Drug Saf 2009,32(10):819–836.PubMedView ArticleGoogle Scholar
- Stefl ME: To Err is Human: Building a Safer Health System in 1999. Front Health Serv Manage 2001,18(1):1–2.PubMedGoogle Scholar
- Moyen E, Camire E, Stelfox HT: Clinical review: medication errors in critical care. Crit Care 2008,12(2):208.PubMed CentralPubMedView ArticleGoogle Scholar
- Aronson JK: Medication errors: what they are, how they happen, and how to avoid them. QJM 2009,102(8):513–521.PubMedView ArticleGoogle Scholar
- Graham AS: Prescribing errors. J Health Syst Pharm 2008, 5–15.Google Scholar
- Evans J: Prevalence, risk factors, consequences and strategies for reducing medication errors in Australian hospitals: a literature review. Contemp Nurse 2009,31(2):176–189.PubMedView ArticleGoogle Scholar
- Kaushal R, Jaggi T, Walsh K, Fortescue EB, Bates DW: Pediatric medication errors: what do we know? What gaps remain? Ambul Pediatr 2004,4(1):73–81.PubMedView ArticleGoogle Scholar
- Stucky ER: Prevention of medication errors in the pediatric inpatient setting. Pediatrics 2003,112(2):431–436.PubMedView ArticleGoogle Scholar
- Ferner RE: The epidemiology of medication errors: the methodological difficulties. Br J Clin Pharmacol 2009,67(6):614–620.PubMed CentralPubMedView ArticleGoogle Scholar
- Vila-de-Muga M, Colom-Ferrer L, Gonzalez-Herrero M, Luaces-Cubells C: Factors associated with medication errors in the pediatric emergency department. Pediatr Emerg Care 2011,27(4):290–294.PubMedView ArticleGoogle Scholar
- Sanghera N, Chan PY, Khaki ZF, Planner C, Lee KKC, Cranswick NE, Wong ICK: Interventions of hospital pharmacists in improving drug therapy in children: a systematic literature review. Drug Saf 2006,29(11):1031–1047.PubMedView ArticleGoogle Scholar
- Gonzales K: Medication administration errors and the pediatric population: a systematic search of the literature. J Pediatr Nurs 2010,25(6):555–565.PubMedView ArticleGoogle Scholar
- Feinberg J, Med Pass Survey: A continuous quality improvement approach. In Edited by: ASCP. 2003.Google Scholar
- Drug Administration and Control Authority of Ethiopia: Standard treatment guideline for general hospitals. 2010.Google Scholar
- Ministry of Health Ethiopia and WHO: Pocket book of pediatric hospital care: Ethiopia. Guidelines for the management of common illnesses in hospitals. 2010.Google Scholar
- Al- Jeraisy MI, Alanazi MQ, Abolfotouh MA: Medication prescribing errors in a pediatric inpatient tertiary care setting in Saudi Arabia. BMC Res Notes 2011, 4:294–299.PubMed CentralPubMedView ArticleGoogle Scholar
- Alaqha HZ, Badary OA, Ibrahim HM, Sabri NA: Reducing prescribing errors in the paediatric intensive care unit:an experience from Egypt. Foundation Acta Pædiatrica 2011, 100:169–174.View ArticleGoogle Scholar
- Folli HL, Poole RL, Benitz WE, Russo JC: Medication error prevention by clinical pharmacists in Two Children’s hospitals. Pediatrics 1987,79(5):718–723.PubMedGoogle Scholar
- Ghaleb MA, Barber N, Franklin BD, Wong ICK: The incidence and nature of prescribing and medication administration errors in paediatric inpatients. Arch Dis Child 2010, 95:113–118.PubMedView ArticleGoogle Scholar
- Condren M, Studebaker IJ, John BM: Prescribing Errors in a Pediatric Clinic. Clin Pediatr 2010,49(1):49–53.View ArticleGoogle Scholar
- Monica VLC, Mariona G, Carles LC: Factors Associated With Medication Errors in the Pediatric Emergency Department. Pediatr Emerg Care 2011,27(4):290–294.View ArticleGoogle Scholar
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